Aspergillus nidulans natural product biosynthesis is regulated by mpkB, a putative pheromone response mitogen-activated protein kinase.

نویسندگان

  • Ali Atoui
  • Dapeng Bao
  • Navgeet Kaur
  • W Scott Grayburn
  • Ana M Calvo
چکیده

The Aspergillus nidulans putative mitogen-activated protein kinase encoded by mpkB has a role in natural product biosynthesis. An mpkB mutant exhibited a decrease in sterigmatocystin gene expression and low mycotoxin levels. The mutation also affected the expression of genes involved in penicillin and terrequinone A synthesis. mpkB was necessary for normal expression of laeA, which has been found to regulate secondary metabolism gene clusters.

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عنوان ژورنال:
  • Applied and environmental microbiology

دوره 74 11  شماره 

صفحات  -

تاریخ انتشار 2008